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Liquid Chromatography- Mass Spectrometer (LC-MS) system
Instrument Details
- Make : M/s Waters
- Model : SQD2 with H-class UPLC
Specifications :
- Single Quadrupole Mass Spectrometer
- System has ESI and APCI as well as positive and negative modes of ionization
- Mass Range: 20 to 2000 m/z
PDA Detector:
- Aquity UPLC PDAeʎ Detector
- Wavelength range: 200 nm to 600 nm
Solvent Delivery System
- High pressure binary gradient pump with online degassing unit
- Mode of operation: Isocratic and gradient
- Flow rate range: 50 µl/min to 500 µl /min
Injector and Autosampler with temperature control
- Temperature range: from 8 °C to 40 °C
- Injection volume range: 0.5 μl to 10 μl
Working Principle: Liquid chromatography- Mass Spectroscopy (LC- MS) is a technique which combines high performance liquid chromatography (HPLC), a powerful analytical separation technique with mass spectroscopy (MS), a powerful analysis & detection technique. Electrospray Ionization (ESI) is a soft ionization technique most widely used in modern times MS and is compatible with most chromatographic separations. HPLC seperations can be detected by “Photo Diode Array (PDA)” detector and Mass spectrometer as different detectors. PDA has three dimensional projection over entire UV-VIS range. It is non-destructive detector so it can be put in series like HPL C-PDA Mass Spectrometer.
Applications:
- Qualitative Analysis
- Quantitative Analysis
- Impurity Profiling
- Metabolite Studies
- Pharmacokinetics
- Pharma & biomedical applications
Charges:
|
SNo. |
Activity |
Charges ( in Rs.) |
Remarks |
|
|
Industry/Private University/ Institutes |
Govt University/ Institutes/National Lab/R&D’s/ |
|||
|
1. |
Only MS with ESI |
4000 |
2000 |
Per sample |
|
2. |
LCMS with ESI for first peak |
8000 |
4000 |
Per sample |
|
3. |
HPLC with PDA detector |
6000 |
3000 |
Per sample |
|
4. |
HPLC + PDA detector + Mass Spectrometer |
12000 |
6000 |
Per sample |
User Instructions :
- Solvent for mobile phase should be mentioned or solubility of compound in volatile solvent should be given.
- LC of submitted samples indicating the operating conditions should be supplied along with the sample.
- Source of the compound should be mentioned.
- MS-DS (Material Safety Data Sheet) should be given along with samples to ensure that there are no toxic sample being given.
- Samples should not be toxic or hazardous. Samples will not be accepted unless accompanied by MS-DS.
Contact Us:
- Director, ICAR-CPRI,Shimla(H.P.)-171001
- Phone: 0177-2625073
- Mobile:+91-9816031628
- Email Id: director.cpri@icar.gov.in